(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen; Abacavir - In House Impurity; Abacavir Impurities; Abacavir Intermediates
杂质:
Abacavir - In House Impurity
CAS号:
188062-50-2
备用CAS:
free base: 136470-78-5
分子式:
C₂₈H₃₈N₁₂O₆S
状态：
白色至白色固体
熔点：
>205°C (dec.)
分子量:
670.74
储存：
-20°C Freezer, Under inert atmosphere
溶解性:
Methanol (Slightly), Water (Slightly)
类别:
Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
Abacavir Sulfate (Abacavir - In House Impurity) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
您的位置：
