产品名称：Abacavir 5’-β-D-Glucuronide Sodium Salt
产品CAS：
规格含量：2mg
产品价格：面议
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产品详细介绍
标准品编号:
A104985
名称:
Abacavir 5’-β-D-Glucuronide Sodium Salt
别名:
[(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopenten-1-yl]methyl-β-D-Glucopyranosiduronic Acid Sodium Salt; Abacavir 5’-Glucuronide Sodium Salt
备用CAS:
384329-76-4 free acid
分子式:
C₂₀H₂₅N₆NaO₇
状态：
Pale Beige Solid
熔点：
>206°C (dec.)
分子量:
484.44
储存：
Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解性:
Methanol (Slightly), Water (Slightly)
稳定性:
Hygroscopic
类别:
Standards; Enzyme Activators and Inhibitors;
应用:
Abacavir 5’-β-D-Glucuronide is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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