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艾塞那肽, 97%
产品基本信息
产品编号:107854
产品名称:艾塞那肽, 97%
产品CAS:141758-74-9
规格含量:0.5mg
产品价格:3000
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产品详细介绍

  艾塞那肽, 97%

  Product Name: Exendin-4
  CAS号:141758-74-9
  分子式:C184H282N50O60S
  分子量:4186.57
  介绍: Exendin-4是一种39个氨基酸的多肽
  用途: Exendin-4能激活GLP-1受体,使该受体增加胰腺腺泡细胞(pancreatic acinar cells)的细胞内cAMP水平,但对VIP受体无效果。
  贮存: 储存温度 -20°C
  生化和生理学机理:
  Exendin-4, a 39 amino acid peptide, activates GLP-1 (glucagon-like peptide-1) receptors to increase intracellular cAMP in pancreatic acinar cells and has no effect on VIP receptors. Exendin-4 stimulates proliferation of HCAECs through PKVIP(LA)PI3K/Akt-eNOS activation pathways via a GLP-1(glucagon-like peptide-1) receptor-dependent mechanism. Exendin-4, the long-acting GLP-1 receptor agonist, is an incretin mimetic approved for type 2 diabetes mellitus treatment. Studies also demonstrated its neurotrophic/protective activity in cellular and animal models of stroke, Alzheimer's and Parkinson's diseases.


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