柔红霉素 盐酸盐, ≥90% (HPLC)
Product Name： Daunorubicin hydrochloride
别名:道诺霉素 盐酸盐
CAS号:23541-50-6
分子式:C27H29NO10 · HCl
分子量:563.98
贮存： 储存温度2-8°C
生化和生理学机理：
IC50 value： 0.02uM (Ki for inhibition of DNA synthesis) Daunomycin is an important anti-tumor agent, mainly used in the treatment of acute leukemias. Daunomycin can inhibit DNA synthesis by the way of binding to DNA(intercalation), causing an increase in the melting temperature of the DNA. in vitro： At Daunorubicin concentrations exceeding approximately 2-4 μM, free radical mediated toxicity and DNA cross-linking may become evident. Daunorubicin inhibits both DNA and RNA syntheses in HeLa cells over a concentration range of 0.2 through 2 μM. Daunorubicin inhibits both DNA syntheses in Ehrlich ascites tumor cells over a concentration range of 4 μM. Daunorubic triggers apoptosis at concentrations of 0.5 and 1 μM in either HL-60 or U-937 human leukemic cells [1]. Daunorubicin stimulates ceramide elevation and apoptosis in P388 and U937 cells through de novo synthesis via activation of the enzyme ceramide synthase[2]. Daunorubicin dose-dependently increases the phosphatidylserine exposure and consequent procoagulant activity of human umbilical vein endothelial cells. Daunorubicin (0.2 mM) significantly enhances the release of endothelial microparticles which are highly procoagulant in human umbilical vein endothelial cells[3]. in vivo： daunorubicin inhibited the proliferation of KG1a cells in a dose and time dependent manner (r = 0.983, P < 0.01).Daunorubicin could reduce the mRNA and protein levels of Eps8 expression in dose and time dependent manners in KG1a cells (r = 0.979, P < 0.05) [4]. Clinical trial： N/A
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