YK-4-279
Product Name： YK-4-279
CAS号:1037184-44-3
分子式:C17H13Cl2NO4
分子量:366.2
贮存： 储存温度-20°C
可溶性： DMSO ≥100mg/mL
生化和生理学机理：
YK-4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. YK-4-279 inhibits Ewing's sarcoma family tumor (ESFT) cell growth; YK-4-279 induces apoptosis. ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA.
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