喷昔洛韦，≥99％
Product Name： Penciclovir
别名:6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-
CAS号:39809-25-1
分子式:C10H15N5O3
分子量:253.26
介绍： Penciclovir
贮存： 储存温度-20°C
可溶性：
DMSO 34 mg/mL
Water 1 mg/mL
Ethanol <1 mg/mL
生化和生理学机理：
Description： IC50 Value： 2.3±0.8 mg/ml(EC50, inhibition EBV DNA synthesis); >100mg/ml(50% cell growth inhibitory concentration of both P3HR-1 and Raji cells) Penciclovir, a novel acyclic nucleoside analogue, has demonstrated efficacy against HSV types 1 and 2 and seems to have a pharmacological advantage due to a prolonged half-life of its active form in HSV-infected cells[1]. in vitro： Treatment with GCV or PCV induced rapid accumulation of cells in S-phase and apoptotic death, GCV (and to a lesser extent PCV) increased phosphatidyl serine translocation, induced positive TUNEL results with alterations in cell morphology, caused marked propidium iodide staining and induced DNA laddering. [2]. B-95-8 cells were treated with penciclovir or aciclovir at 1 and 10 ug/ml for 7 days, At 1 ug/ml, both compounds were inactive, but at 10 ug/ml, the virus yield relative to that of untreated virus controls was reduced by 94 and 86% by penciclovir and aciclovir, respectively[5]. in vivo： Penciclovir pharmacokinetics following oral administration of famciclovir were nonlinear within the dosage range studied, likely because of saturation of famciclovir metabolism[3]. Treatment with penciclovir (intravenous formulation) was associated with the development of resistant HSV in only one severely immunocompromised patient (day 7 isolate IC(50) = 2.01 microg/ml), although treatment was effective and resulted in the complete clearance of the lesion by day 8. No patients receiving topical penciclovir developed treatment-associated penciclovir-resistant HSV[4]. Clinical trial： A Comparative Study of the Efficacy of Penciclovir 10 mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers. Phage4
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