产品编号：T779315

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	T779315
名称:	1-(2-Thiazolylazo)-2-naphthol
别名:	NSC139021;1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol; (1Z)-1-(1,3-thiazol-2-ylhydrazinylidene)naphthalen-2-one; ERGi-USU;(2-Thiazolylazo)-2-naphthol; 1-(1,3-Thiazolyl-2-azo)-2-naphthol; 1-(2-Thiazolylazo)-2-naphthol; NSC 139021; TAN; TAN (spectrophotometric reagent); β-TAN
CAS号:	1147-56-4
分子式:	C₁₃H₉N₃OS
分子量:	255.3
类别:	Standards; Enzyme Activators and Inhibitors;
应用:	1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
参考文献	Chen, Jianrong., et al.: Anal Chim Acta., 450,Â215Â(2001); Visser, Ann E., et al.: Sep. Sci. Technol., 36,Â785Â(2001); Stauber, J. L., et al.: Marine Biology., 94,Â511Â(1987)