产品编号：T767675

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	T767675
名称:	N4,3',5'-Tribenzoyl,2'-deoxy-2'β-fluoro-2'C-α-methyl Cytidine
别名:	(2R,3R,4S,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl Benzoate
分子式:	C₃₁H₂₆FN₃O₇
分子量:	571.55
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	N4,3',5'-Tribenzoyl,2'-deoxy-2'β-fluoro-2'C-α-methyl Cytidine is an impurity of Sofosbuvir (P839640); a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
参考文献	Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)