产品编号：T700500

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	T700500
名称:	TPCVIP(LA)1
别名:	2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide; 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxylic acid amide; IKK 2 Inhibitor IV; TPCA 1
CAS号:	507475-17-4
分子式:	C₁₂H₁₀FN₃O₂S
外观:	Pale Beige Solid
熔点:	>217°C (dec.)
分子量:	279.29
储存:	-20°C Freezer
溶解度:	DMSO (Slightly), Methanol (Slightly)
类别:	Research Tools; Enzyme Activators and Inhibitors;
应用:	TPCVIP(LA)1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCVIP(LA)1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.
参考文献	Nan, J., et al.: Mol. Cancer Ther., 13, 617 (2014); Birrell, M.A., et al.: Am. J. Respir. Crit. Care Med., 172, 962 (2005); Birrell, M.A., et al.: Mol. Pharmacol., 69, 1791 (2006)