产品编号：T006002
产品规格：10mg
产品价格：面议
| 标准品编号: | T006002 |
| 名称: | Tamoxifen-13C6 |
| 别名: | (Z)-2-[4-[1-(phenyl-13C6)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine; ICI 47699-13C6; Mammaton-13C6; Novaldex-13C6; Tamoxifen-13C6; Z-Tamoxifen-13C6; trans-Tamoxifen-13C6; |
| CAS号: | 1346606-38-9 |
| 参考CAS号: | 类似: 10540-29-1 |
| 分子式: | C₂₀¹³C₆H₂₉NO |
| 外观: | 白色固体 |
| 熔点: | 94 - 99°C |
| 分子量: | 377.47 |
| 储存: | Amber Vial, -20°C Freezer |
| 溶解度: | Chloroform (Slightly), Methanol (Slightly) |
| 类别: | Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. |
| 参考文献 | |
