产品编号：T006000
产品规格：1g
产品价格：面议
| 标准品编号: | T006000 |
| 名称: | Tamoxifen |
| CAS号: | 10540-29-1 |
| 分子式: | C₂₆H₂₉NO |
| 外观: | 白色至白色固体 |
| 熔点: | >92°C (dec.) |
| 分子量: | 371.52 |
| 储存: | Amber Vial, -20°C Freezer |
| 溶解度: | Chloroform (Sparingly), Methanol (Slightly) |
| 稳定性: | Light Sensitive |
| 类别: | Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites; |
| 应用: | Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells. |
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