产品编号：T004870

产品规格：25 mg

产品价格：面议

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产品详情

标准品编号:	T004870
名称:	TAK 632
别名:	N-[5-[[7-Cyano-2-[(cyclopropylcarbonyl)amino]-6-benzothiazolyl]oxy]-2-fluorophenyl]-3-(trifluoromethyl)-benzeneacetamide; ‡N-[7-Cyano-6-[4-fluoro-3-[[[3-(trifluoromethyl)phenyl]acetyl]amino]phenoxy]-1,3-benzothiazol-2-yl]cyclopropanecarboxamide;
CAS号:	1228591-30-7
分子式:	C₂₇H₁₈F₄N₄O₃S
分子量:	554.52
类别:	Research Tools;
应用:	TAK-632 is a selective pan-RAF inhibitor. It exhibits antitumor activity by inducing RAF dimerization but inhibiting its kinase activity in BRAF- and NRAS-mutated with acquired resistance to BRAF inhibitor in human and mouse melanoma cell.
参考文献	Nakamura, A., et al.: Cancer Res., 73, 7043 (2013); Okaniwa, M., et al.: J. Med. Chem., 56, 6478 (2013)

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