产品编号：S675600

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	S675600
名称:	Sofosbuvir Carboxylic Acid
别名:	(S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoic Acid
分子式:	C₁₉H₂₃FN₃O₉P
分子量:	487.37
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Sofosbuvir Carboxylic Acid is an impurity of Sofosbuvir (P839640); a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
参考文献	Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)