产品编号：S115000
产品规格：5mg
产品价格：面议
| 标准品编号: | S115000 |
| 名称: | SANT-1 |
| 别名: | N-[(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine |
| CAS号: | 304909-07-7 |
| 分子式: | C₂₃H₂₇N₅ |
| 外观: | 白色至淡黄色固体 |
| 熔点: | 108-111°C |
| 分子量: | 373.49 |
| 储存: | -20°C Freezer |
| 溶解度: | Chloroform (Slightly), Methanol (Slightly) |
| 类别: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | A potent antagonist of the sonic hedgehog (Shh) signaling pathway (IC50=20nm inShh-LIGHT2 assay an d in Ptch1-/- cells) that acts by binding to smoothened (Smo: KD=1.2 nM), a distant relative of G protein-coupled receptors. In contrast to cyclopamine, SNAT-1 inhibits the activities of both wild type and oncogenic Smo with equal potency (IC50=30nm in SmoA1-LIGHT2 assay). |
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