产品编号：Q700550

产品规格：1g

产品价格：面议

---

产品详情

标准品编号:	Q700550
名称:	2,3-Quinolinedimethanol
别名:	Quinoline-2,3-diyldimethanol
CAS号:	57032-14-1
分子式:	C₁₁H₁₁NO₂
分子量:	189.21
类别:	Building Blocks; Miscellaneous;
应用:	2,3-Quinolinedimethanol is a reactant used in the synthesis of camptothecin (C175150), an ntitumor alkaloid which binds irreversible to the DNVIP(LA)topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent
参考文献	Xu, P., et. al.: Chem-Asian J., 10, 976 (2015)Potmesil, M., et al.: Cancer Res., 54, 1431 (1994); Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997); Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998); Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998)