产品编号：P688260

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P688260
名称:	Ponatinib N-Oxide
别名:	3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide N-Oxide;
参考CAS号:	Free Base: 943319-70-8
分子式:	C₂₉H₂₇F₃N₆O₂
分子量:	548.56
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Ponatinib N-Oxide is derived from Ponatinib (P688250), which is a tyrosine kinase inhibitors (TKI) and used to treat chronic myeloid leukemia (CML) (1,2,3). Ponatinib is also used in combination with other drugs, such as forskolin, to combat TKI resistance in patient with CML (3), targeted drug in small-cell lung cancer. Potent FAK inhibitor. FGFR/VEGFR/Bcr-Abl inhibitor.
参考文献	De L., et al.: J. Pharmacol. Exp. Ther., 363, 12-19 (2017), Arts, F. A., et al.: Hum. Mol. Genet., 26, 1801-1810 (2017)