产品编号：P571500

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P571500
名称:	PK 11195
别名:	1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; N-Methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide; RP 52028;
CAS号:	85532-75-8
分子式:	C₂₁H₂₁ClN₂O
分子量:	352.86
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.
参考文献	Azarashvili, T. et al.: J. Neurochem., 94, 1054 (2005); Le Fur, G. et al.: Life Sci., 33, 449 (1983); Walter, R.B. et al.: