产品编号：P309050

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	P309050
名称:	1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride
别名:	4-Keto-1-phenyl-2,3-dihydroisoquinoline Hydrochloride
分子式:	C₁₅H₁₄ClNO
分子量:	259.73
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	1-Phenyl-2,3-dihydroisoquinolin-4(1H)-one Hydrochloride is a useful synthetic intermediate in the synthesis of cis-Hydroxy Solifenacin (H953525) and cis-Hydroxy Solifenacin N-Oxide (H953485); both metabolites of Solifenacin (S676700, HCl) which is a muscarinic M3 receptor antagonist and is used in treatment of urinary incontinence.
参考文献	Naito, R., et al.: J. Med. Chem., 48, 6597 (2005); Krauwinkel, W., et al.: Int. J. Clin. Pharmacol. Ther., 43, 227 (2005); Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)