产品编号：P294010

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P294010
名称:	PF-4708671
别名:	2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; PF 4708671;
CAS号:	1255517-76-0
分子式:	C₁₉H₂₁F₃N₆
外观:	Pale Purple Solid
熔点:	>186°C (dec.)
分子量:	390.41
储存:	-20˚C Freezer
溶解度:	DMSO (Slightly, Sonicated), Methanol (Slightly)
类别:	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.
参考文献	Pearce, L.R. et al.: Biochem. J., 431, 245 (2010);