产品编号：P217477

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	P217477
名称:	PD-123319-d6 Bis(Trifluoroacetic Acid Salt) Salt Hydrate
别名:	(6S)-1-[[4-(Dimethylamino-d6)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic Acid Bis(trifluoroacetate) Salt Hydrate; (S)-(+)-PD 123319-d6 Bis(trifluoroacetate) Salt Hydrate;
CAS号:	1346603-57-3
参考CAS号:	Unlabelled Freeacid: 130663-39-7; Unlabelled anhyd
分子式:	C₃₁H₂₆D₆N₄O₃•2C₂HF₃O₂•xH₂O
分子量:	742.69
类别:	Standards; Isotopic Labeled Analogues; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	A labelled selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells
参考文献	Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);