产品编号：O902770

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	O902770
名称:	(2E)-2-​[(4-​Oxo-​4H-​1-​benzopyran-​3-​yl)​methylene]​hydrazinecarbothioamide
CAS号:	902779-62-8
分子式:	C₁₁H₉N₃O₂S
外观:	白色固体
分子量:	247.27
储存:	冰箱 (0°C)
溶解度:	DMSO-d6
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(2E)-2-​[(4-​Oxo-​4H-​1-​benzopyran-​3-​yl)​methylene]​hydrazinecarbothioamide is an intermediate in the synthesis of Akt inhibitor XI (A450500), which inhibits Akt in various cancer cells. Protein kinase B (PKB or Akt) is aserene/threonine kinase, which is involved in a wide variety of cellular processes including metabolism, apoptosis and cell proliferation. Furthermore,Akt inhibitor XIwas employed in a biological study that aimed to develop a novel coiled-coil three-hybrid system that can identify potential allosteric inhibitors.
参考文献	Dan, S., et al.:ÂCancer Res. 70, 4982 (2010); Jester, B. W., et al.: J. Am. Chem. Soc. 132, 11727 (2010);ÂJester, B. W., et al.: J. Med. Chem. 55, 1526 (2012);ÂFedichev, P. O. and Vinnik, A. A. PCT Int. Appl. WOÂ2013147649ÂA2Â20131003 (2013)