产品编号：O858760

产品规格：25mg

产品价格：面议

---

产品详情

标准品编号:	O858760
名称:	4-Oxo-4H-pyran-2,5-dicarboxylic Acid 2,5-Diethyl Ester
CAS号:	1246616-74-9
分子式:	C₁₁H₁₂O₆
分子量:	240.21
类别:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	4-Oxo-4H-pyran-2,5-dicarboxylic Acid 2,5-Diethyl Ester is an intermediate used in the synthesis of Defluoro Dolutegravir (D228715), which is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
参考文献	Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);