产品编号：O848430

产品规格：5g

产品价格：面议

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产品详情

标准品编号:	O848430
名称:	(1R,​4S)​-3-​Oxo-2-​azabicyclo[2.2.1]​hept-​5-​ene-​2-​carboxylic acid 1,​1-​Dimethylethyl Ester
别名:	(1R,4S)-(-)-2-t-Butoxycarbonyl-2-azabicyclo[2.2.1]hept-5-en-3-one;(1R,4S)-t-Butyl 3-oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate; (1R)-3-Oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylic Acid 1,1-Dimethylethyl Ester
CAS号:	151792-53-9
分子式:	C₁₁H₁₅NO₃
分子量:	209.24
类别:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(1R,​4S)​-3-​Oxo-2-​azabicyclo[2.2.1]​hept-​5-​ene-​2-​carboxylic acid 1,​1-​Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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