产品编号：N515877

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	N515877
名称:	2-(4-Nitro-1,3-dioxoisoindolin-2-yl)pentanedioic Acid-d4
别名:	2-(1,3-Dihydro-4-nitro-1,3-dioxo-2H-isoindol-2-yl)pentanedioic Acid-d4;1-(4-Nitro-1,3-dioxoisoindolin-2-yl)propane-1,3-dicarboxylic Acid-d4
CAS号:	1416575-82-0
参考CAS号:	18636-08-3
分子式:	C₁₃H₆D₄N₂O₈
外观:	Yellow Solid
分子量:	326.25
溶解度:	DMF; Methanol
种类:	Building Blocks; Isotopic Labeled Analogues; Miscellaneous;
应用:	2-(4-Nitro-1,3-dioxoisoindolin-2-yl)pentanedioic Acid-d4 is an intermediate for the synthesis of Pomalidomide-(d4 major) (P688202), which is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
参考文献	Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)