产品编号：N515875

产品规格：50mg

产品价格：面议

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产品详情

标准品编号:	N515875
名称:	2-(4-Nitro-1,3-dioxoisoindolin-2-yl)pentanedioic Acid
别名:	2-(1,3-Dihydro-4-nitro-1,3-dioxo-2H-isoindol-2-yl)pentanedioic Acid;1-(4-Nitro-1,3-dioxoisoindolin-2-yl)propane-1,3-dicarboxylic Acid
CAS号:	18636-08-3
分子式:	C₁₃H₁₀N₂O₈
外观:	Yellow Solid
分子量:	322.23
溶解度:	DMF; Methanol
种类:	Building Blocks; Miscellaneous;
应用:	2-(4-Nitro-1,3-dioxoisoindolin-2-yl)pentanedioic Acid is an intermediate in the synthesis of Pomalidomide (P688200), a thalidomide derivative and a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
参考文献	Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)