产品编号：N515870

产品规格：25mg

产品价格：面议

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产品详情

标准品编号:	N515870
名称:	2-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-4-nitroisoindoline-1,3-dione
别名:	4-Nitro-2-(tetrahydro-2,6-dioxo-2H-pyran-3-yl)-1H-isoindole-1,3(2H)-dione;2-(3'-Nitrophthalimido)glutaric Anhydride
CAS号:	6383-80-8
分子式:	C₁₃H₈N₂O₇
外观:	Yellow Solid
分子量:	304.21
溶解度:	DMF; DMSO
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	2-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-4-nitroisoindoline-1,3-dione is an intermediate in the synthesis of Pomalidomide (P688200), a thalidomide derivative and a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
参考文献	Ruchelman, A. et al.: Bioorg. Med. Chem. Lett., 23, 360 (2013); Latif, T. et al.: Exp. Hematol. Oncol., 1, 27 (2012); Man, H. et al.: Bioorg. Med. Chem. Lett., 13, 3415 (2003); Muller, G. et al.: Bioorg. Med. Chem. Lett., 9, 1625 (1999)