产品编号：N388750

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	N388750
名称:	trans-Ned-19
别名:	(1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid;
CAS号:	1354235-96-3
参考CAS号:	1137263-70-7 (for relative stereochem)
分子式:	C₃₀H₃₁FN₄O₃
外观:	Yellow Solid
熔点:	168-173°C
分子量:	514.59
储存:	冰箱
溶解度:	Methanol
种类:	Standards; Enzyme Activators and Inhibitors; Fluorescent Reagents; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	trans-Ned-19 is a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells.
参考文献	Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009); Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009); Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009);