产品编号：M884400

产品规格：2mg

产品价格：面议

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产品详情

标准品编号:	M884400
名称:	Myriocin
别名:	(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic Acid;
CAS号:	35891-70-4
分子式:	C₂₁H₃₉NO₆
外观:	白色至白色固体
熔点:	>175°C (dec.)
分子量:	401.54
储存:	Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度:	DMSO (Sparingly), Methanol
种类:	Standards; Chiral Molecules; Amino Acids; Enzyme Activators and Inhibitors; Others; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
应用:	Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin is a useful biochemical research tool for depleting cells of sphingolipids.
参考文献	Miyake, Y., et al.: Biochem. Biophys. Res. Commun., 211, 396 (1995); Hidari, K.I.P.J. et al.: J. Biol. Chem., 271, 14636 (1996); Nakamura, S. et al.: J. Biol. Chem., 271, 1255 (1996); De Zélicourt, A. et al.: Planta 230, 1047 (2009); Kluepfel, D., et al.: J. Antib., 25, 109 (1972)