产品编号：M425030

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	M425030
名称:	MK-2048
别名:	(6S)-2-(3-Chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide;
CAS号:	869901-69-9
分子式:	C₂₁H₂₁ClFN₅O₄
外观:	Yellow Solid
熔点:	>240°C (dec.)
分子量:	461.87
储存:	-20°C Freezer
溶解度:	DMSO (Slightly), Methanol (Slightly)
种类:	Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.
参考文献	Tamara, B.M. et al.: J. Virol., 10, 1128 (2010);