产品编号：M323795

产品规格：25mg

产品价格：面议

---

产品详情

标准品编号:	M323795
名称:	(R)-4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
别名:	(αR)-α-[3-(Methylnitrosoamino)propyl]-3-pyridinemethanol; (R)-α-[3-(Methylnitrosoamino)propyl]-3-pyridinemethanol; (R)-NNAL
CAS号:	197711-99-2
参考CAS号:	S-enantiomer: 197712-01-9
分子式:	C₁₀H₁₅N₃O₂
分子量:	209.24
种类:	Standards; Environmental Standards, Mutagens and Metabolites; Nicotine Derivatives and Metabolites;
应用:	(R)-4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol is the R-enantiomer of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which is a major metabolite of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (M325750). It is a tobacco specific N-nitrosamine (TSNA) and a potent pulmonary carcinogen. The R-enantiomer of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, (R)-NNAL, tends to be significantly more tumorigenic than the S-entiomer, (S)-NNAL.
参考文献	Yang, Y.Y., et al.: J. Chromatogr. A, 1218, 6505 (2011); Carmella, S.G., et al.: J. Cancer Res., 53, 721 (1993); Upadhyaya, P., et al.: Carcinogenesis, 20, 1577 (1999)