产品编号：K660400

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	K660400
名称:	KU-0058948
别名:	4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; KU 0058948; KU0058948; 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine;
CAS号:	763111-49-5
分子式:	C₂₁H₂₁FN₄O₂
外观:	Pale Yellow to Yellowish Beige Solid
熔点:	>150°C (dec.)
分子量:	380.42
储存:	冰箱
溶解度:	DMSO (Slightly), Methanol (Slightly)
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro
参考文献	Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);

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