产品编号：K450000
产品规格：2.5mg
产品价格：面议
| 标准品编号: | K450000 |
| 名称: | Kifunensine |
| 别名: | [5R-(5α,6β,7α,8α,8aα)]-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione; (+)-Kifunensine; FR 900494 |
| CAS号: | 109944-15-2 |
| 分子式: | C₈H₁₂N₂O₆ |
| 外观: | 白色至白色固体 |
| 熔点: | >208°C (dec.) |
| 分子量: | 232.19 |
| 储存: | -20°C Freezer |
| 溶解度: | DMSO (Slightly, Heated), Methanol (Slightly), Water (Very Slightly, Heated) |
| 稳定性: | Desiccate and Store at -20°C |
| 种类: | Standards; Enzyme Activators and Inhibitors; Glycosidase Inhibitors; |
| 应用: | Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis. When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin. Ph |
| 参考文献 | |
