产品编号：I821765
产品规格：250mg
产品价格：面议
| 标准品编号: | I821765 |
| 名称: | Isonicotinic Acid Vanillylidenehydrazide |
| 别名: | Ftivazid; Ftivazide; N-Isonicotinamido-3-methoxy-4-hydroxybenzalimine; NSC 31725; Phthivazid; Phthivazide; Vanicid; Vanillaberon; Vanizide; [(4-Hydroxy-3-methoxyphenyl)methylene]hydrazide 4-Pyridinecarboxylic Acid; |
| CAS号: | 149-17-7 |
| 分子式: | C₁₄H₁₃N₃O₃ |
| 分子量: | 271.27 |
| 种类: | Standards; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics; |
| 应用: | Isonicotinic Acid Vanillylidenehydrazide exhibits anti-mycobacterial activity against Mycobacterium tuberculosis and anti-microbial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger. Also, it is derived from Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic). |
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