产品编号：H942223

产品规格：250mg

产品价格：面议

---

产品详情

标准品编号:	H942223
名称:	N-​[(1R,​4S)​-​4-​(Hydroxymethyl)​-​2-​cyclopenten-​1-​yl]​-carbamic Acid 1,​1-​Dimethylethyl Ester
别名:	(1R-cis)-[4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester; [(1R,​4S)​-​4-​(Hydroxymethyl)​-​2-​cyclopenten-​1-​yl]​-carbamic Acid 1,​1-​Dimethylethyl Ester
CAS号:	168960-18-7
分子式:	C₁₁H₁₉NO₃
外观:	Yellow Oil
分子量:	213.27
溶解度:	DMSO; Methanol
种类:	Building Blocks; Miscellaneous;
应用:	N-​[(1R,​4S)​-​4-​(Hydroxymethyl)​-​2-​cyclopenten-​1-​yl]​-carbamic Acid 1,​1-​Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
参考文献