产品编号：H939485

产品规格：1mg

产品价格：面议

---

产品详情

标准品编号:	H939485
名称:	2'-(R)-Hydroxy-2',3'-dihydroabacavir Dihydrochloride
别名:	3-Hydroxy Abacavir
分子式:	C₁₄H₂₀N₆O₂•2HCl
分子量:	304.357292
种类:	Standards; Chiral Molecules; Nucleic Acid; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	2'-(R)-Hydroxy-2',3'dihydroabacavir is the impurity ofAbacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
参考文献