产品编号：H938495

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	H938495
名称:	(E)-4-Hydroxy-N-desmethyl Tamoxifen
别名:	4-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; E-Endoxifen
CAS号:	114828-90-9
分子式:	C₂₅H₂₇NO₂
外观:	白色固体
熔点:	157-159ºC
分子量:	373.49
储存:	-20°C Freezer
溶解度:	Chloroform (Slightly), Methanol (Slightly)
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
参考文献	Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),