产品编号：G766103
产品规格：10mg
产品价格：面议
| 标准品编号: | G766103 |
| 名称: | GNE-3511 |
| 别名: | 2-[[6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-4-pyridinecarbonitrile |
| CAS号: | 1496581-76-0 |
| 分子式: | C₂₃H₂₆F₂N₆O |
| 分子量: | 440.49 |
| 种类: | Standards; Enzyme Activators and Inhibitors; |
| 应用: | GNE-3511 is a potent and selective dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. GNE-3511 displays concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. GNE-3511 displays protection of primary neurons in an in vitro axon degeneration assay as well as activity in the mouse models of glaucoma/optic neuropathy (optic nerve crush) and Parkinson’s disease (MPTP) after oral dosing. |
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