产品编号：G797855

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	G797855
名称:	GSK'872
别名:	N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine; GSK872
CAS号:	1346546-69-7
分子式:	C₁₉H₁₇N₃O₂S₂
分子量:	383.49
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	GSK'872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).
参考文献	Kaiser, William J.; et al.: J. Biol. Chem., 288,31268 (2013);