产品编号：G797853

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	G797853
名称:	GSK-626616
别名:	(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone; GSK 626616
CAS号:	1025821-33-3
分子式:	C₁₈H₁₀Cl₂N₄OS
分子量:	401.27
种类:	Standards; Enzyme Activators and Inhibitors;
应用:	GSK-626616 is a potent and selective DYRK inhibitor (IC50 = 0.7 nM for DYRK3, similar potency for DYRK1 and 2). Exhibits ~20-fold selectivity over casein kinase 2 and negligible activity against a panel of 451 kinases screened. Enhances number of CFU-E stimulated by Epo from human marrow. Increases hemoglobin levels in anemic mice. Orally bioavailable.
参考文献	Wippich, Frank., et al.: Cell., 152,791(2013); Corona, John A., et al.: Org. Process Res. Dev., 14,712(2010)