产品编号：F621098

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	F621098
名称:	Fluorogenic Proteasome Substrate Substrate
别名:	N-[(Phenylmethoxy)carbonyl]-L-valyl-L-lysyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-methioninamide; 1: PN: WO2008077109 PAGE: 7 claimed sequence
CAS号:	141223-71-4
分子式:	C₃₄H₄₅N₅O₇S
分子量:	667.82
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Fluorogenic Proteasome Substrate (Z-VKM-AMC) is used to measure the peptidase activity of the 20S proteasome. Also used as a fluorogenic substrate for Alzheimer's Disease amyloid A4-generating enzymes. AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
参考文献	1. Ishiura, S., et al., 1990. Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue. Neuroscience letters. 115(2-3): 329-34. PMID: 22345092. Koike, H., et al., 1999. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. Journal of biochemistry. 126(1): 235-42. PMID: 103933443. Matsui, Hitoshi., et al., 2002. Presence of angiotensin-converting enzyme in follicular fluids of porcine ovaries and its possible involvement in the intrafollicular breakdown of bradykinin. Molecular reproduction and development. 62(1): 99-105. PMID: 119331664. Hook, Vivian Y H., et al., 2002. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolyti