产品编号：F595665

产品规格：100mg

产品价格：面议

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产品详情

标准品编号:	F595665
名称:	6-(4-Fluorophenyl)-3-morpholinone
CAS号:	951626-54-3
分子式:	C₁₀H₁₀FNO₂
分子量:	195.19
种类:	Building Blocks; Miscellaneous;
应用:	6-(4-Fluorophenyl)-3-morpholinone is a reagent that is used in the synthesis of Aprepitant (A729800), which is a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
参考文献	Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),