产品编号：F401290

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	F401290
名称:	(R)-FL-118
别名:	(R)-7-Ethyl-7-hydroxy-7H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(10H,13H)-dione; 10,11-(Methylenedioxy)-20(R)-camptothecin; (7R)-7-Ethyl-7-hydroxy-10H-1,3-dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione;
CAS号:	151636-76-9
分子式:	C₂₁H₁₆N₂O₆
分子量:	392.36
种类:	Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(R)-FL-118 is a derivative of Camptothecin (C175150), which is antitumor alkaloid that binds to the DNVIP(LA)topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I, trapping the enzyme in a covalent linkage with DNA.
参考文献	Potmesil, M., et al.: Cancer Res., 54, 1431 (1994); Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1997); Fan, Y., et al.: J. Med. Chem., 41, 2216 (1998); Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1998); Del Poeta, M., et al.: Antimicrob. Agents Chemother., 43, 2862 (1999);