产品编号：D293990

产品规格：10mg

产品价格：面议

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产品详情

标准品编号:	D293990
名称:	Des-butanoyl 3,4-Didehydro-N-butyl(2,4-difluorobenzyl)carbamate Dolutegravir
别名:	(R)-3-(7-((2,4-Difluorobenzyl)carbamoyl)-9-hydroxy-1,8-dioxo-1H-pyrido[1,2-a]pyrazin-2(8H)-yl)butyl 2,4-difluorobenzylcarbamate
CAS号:	2244161-73-5
分子式:	C₂₈H₂₄F₄N₄O₆
分子量:	588.51
种类:	Standards; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Des-butanoyl 3,4-Didehydro-N-butyl(2,4-difluorobenzyl)carbamate Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
参考文献	Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);