产品编号：D290752

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	D290752
名称:	O-Desmethyl Astemizole-d5
别名:	4-[2-[4-[[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinyl]ethyl]phenol-d5; Desmethylastemizole-d5; O-Demethylastemizole-d5; R 44271-d5;
参考CAS号:	Unlableled: 73736-50-2
分子式:	C₂₇H₂₄D₅FN₄O
分子量:	449.57
种类:	Standards; Isotopic Labeled Analogues;
应用:	O-Desmethyl Astemizole-d5 is the deuterated form of O-Desmethyl Astemizole (D290750), which is a metabolite of Astemizole;Also, it is derived from N-Carbethoxy-4-piperidone (C176120), which is used in the preparation of 3-hydrazinopyridazines as antihypertensive agents as well as γ-carboline derivatives as potential serotonergic agents. N-Carbethoxy-4-piperidone is also an impurity of Loratadine (L469575).
参考文献	Nagata, K., et al.: J. Biol. Chem., 268, 24720 (1993), Benton, R., et al.: Clin. Pharmacol. Ther., 59, 383 (1996), Hashizume, T., et al.: Drug Metab. Dispos., 26, 566 (1998), Scarborough, P., et al.: Drug Metab. Rev., 31, 205 (1999); Schenker, E. et al.: Arsneim.-Forsch., 29, 1835 (1979); El-Kader, A. et al.: Mans. J. Pharm. Sci., 6, 1 (1989); Albu, M. et al.: J. Liq. Chrom. Rel. Technol., 32, 2569 (2009);