产品编号：D232130

产品规格：1mg

产品价格：面议

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产品详情

标准品编号:	D232130
名称:	(2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine (3-Methyl-1H-imidazol-3-ium-1-yl)phosphonate Triethylammonium Chloride Salt
分子式:	C₁₄H₁₈FN₄O₇P • C₆H₁₆ClN
分子量:	404.2913765
种类:	Research Tools; Molecular Biology; Nucleic Acids;
应用:	(2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine (3-Methyl-1H-imidazol-3-ium-1-yl)phosphonate Triethylammonium Chloride Salt is an intermediate in the synthesis of (2'R)​-2'-​Deoxy-​2'-​fluoro-​2'-​methyl-uridine 5'-​Triphosphate Triethylammonium Salt (D235370), an impurity of Sofosbuvir (P839640). Sofosbuvir is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate.
参考文献	Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)