产品编号：D100087

产品规格：5mg

产品价格：面议

---

产品详情

标准品编号:	D100087
名称:	Dabigatran Acyl-β-D-Glucuronide-d3
别名:	N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine β-D-Glucopyranuronosyl Ester-d3;
参考CAS号:	未标记：1015167-40-4
分子式:	C₃₁H₃₀D₃N₇O₉
分子量:	650.65
种类:	Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	Isotope labelled Dabigatran Acyl-β-D-Glucuronide (D100085) is the major metabolite of Dabigatran (D100090) in humans. Four isomeric acylglucuronides of Dabigatran were isolated and purified from urine of dosed rhesus monkeys. NMR analysis confirmed the structures of the four metabolites as the 1-O-acylglucuronide (β anomer) and the 2-O-, 3-O-, and 4-O-acylglucuronides (α and β anomers).
参考文献	Becker, B., et al.: Biochem. J., 314, 249 (1996), Bailey, M., et al.: Chem. Biol. Interact., 145, 117 (2004), Blech, S., et al.: Drug Metab. Dispos., 2008, 36, 386 (2008),