产品编号：C982940

产品规格：5mg

产品价格：面议

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产品详情

标准品编号:	C982940
名称:	O-Des(Cyclopropylmethyl) O-cyclobutyl Roflumilast
别名:	3-Cyclobutoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
分子式:	C₁₇H₁₄Cl₂F₂N₂O₃
外观:	白色至白色固体
熔点:	134 - 136°C
分子量:	403.21
储存:	-20°C Freezer
溶解性:	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
种类:	Standards; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	O-Des(cyclopropylmethyl) O-cyclobutyl Roflumilast is an intermediate used in the synthesis of Roflumilast (R639700). Roflumilast is a selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.
参考文献	Hatzelmann, A., et al.: J. Pharmacol. Exp. Ther., 297, 267 (2001); Schmidt, B.M.W., et al.: J. Allergy Clin. Immunol., 108, 530 (2001); Timmer, W., et al.: J. Clin. Pharmacol., 42, 297 (2002); Rabe, K.F., et al.: Lancet, 366, 563 (2005);