产品编号：C562500

产品规格：100µg

产品价格：面议

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产品详情

标准品编号:	C562500
名称:	Clasto-lactacystin(Omuralide)
别名:	(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Clasto-lactacystin β-Lactone; Omuralide
CAS号:	154226-60-5
分子式:	C₁₀H₁₅NO₄
外观:	白色固体
熔点:	186-187°C
分子量:	213.23
储存:	-20°C Freezer
溶解度:	DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
类别:	Standards; Enzyme Activators and Inhibitors;
应用:	A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
参考文献	Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997), Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997), Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998), Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)