产品编号：C374175

产品规格：2.5mg

产品价格：面议

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产品详情

标准品编号:	C374175
名称:	(3S,4R)-N-(Chloro(4-nitrophenyl)methyl)-3-(3,4-dimethoxyphenyl)-1-methylpiperidin-4-amine
分子式:	C₂₁H₂₆ClN₃O₄
外观:	Light Brown Solid
分子量:	419.9
溶解度:	Dichloromethane, Ethyl Acetate, Methanol
类别:	Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
应用:	(3S,4R)-N-(Chloro(4-nitrophenyl)methyl)-3-(3,4-dimethoxyphenyl)-1-methylpiperidin-4-amine is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
参考文献	Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),