产品编号：C367720

产品规格：500mg

产品价格：面议

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产品详情

标准品编号:	C367720
名称:	(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
CAS号:	314771-88-5
分子式:	C₁₈H₁₄ClFN₄O₄
分子量:	404.78
类别:	Building Blocks;
应用:	(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
参考文献	Zhang, X., et al.: Bioorg. Med. Chem., 21, 7988 (2013); Ermoli, A. et al.: J. Med. Chem., 52, 4380 (2009); Pearson, S. et al.: Synthesis, 15, 2503 (2005);